Available technologies

Formulations for the Prevention of Neural Tube Defects

Exploring ways to prevent birth defects, researchers at the UCL Institute of Child Health have discovered novel supplements that if taken in pregnancy can reduce the chance of the baby having neural tube defects such as spina bifida or anencephaly. These are important in pregnancies where folic acid and other supplements are not as effective. A new patent has been filed we are supporting work to validate and test combinations in animal models.
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Magnetic Microbubbles

Magnetic microbubbles can be injected into the blood stream and may be directed to a specific body location by the application of an external magnetic field. They enhance ultrasound images, and can be used to deliver, and promote uptake of, cargo molecules such as drugs, antibodies or DNA. They thus have many potential applications in clinical settings, as well as in both basic and medical research.
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SnakeGrid Transformer for CAD

Based on research at UCL Civil, Environmental and Geomatic Engineering Department, SnakeGrid® Transformer is a plug-in software module for the Bentley MicroStation CAD package and allows the conversion of Bentley MicroStation design files "on the fly" between different SnakeGrids®, London Survey Grid, British National Grid settings and local grids such as the Reading Grid.
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LipoGlucoCEST – Novel Imaging Agents for GlucoCEST

GlucoCEST is a magnetic resonance imaging (MRI) technique that enables visualisation of natural, non-radioactive glucose that can be used in cancer diagnosis. However, this technique has limitations due to interactions with the body glucose sensing system.

To solve this problem, researchers at UCL Institute of Neurology and Department of Chemistry have developed a novel set of imaging agents based on liposome-encapsulated sugar compounds that addresses these issues.
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Synthetic engineered potassium channel (EKC) for gene therapy

Epilepsy affects around 60 million people globally and there remains an urgent need for novel treatment methods. Researchers at UCL Institute of Neurology have developed a novel synthetic engineered potassium channel (EKC) as a gene therapy tool to treat epilepsy and other neurological conditions. The inventors have preclinical results demonstrating their engineered potassium channel reduces seizures in a rodent model of epilepsy.
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Tau-gene-specific non-coding RNA genes for the therapeutic reduction of tau levels

During genome transcription, both coding and non-coding transcripts are generated with a wide range of both size and coding potential. Among these are long non-coding RNA (lncRNA) genome transcripts, some of which are antisense to protein-coding genes (AS-lncRNAs). These AS-lncRNAs have been shown to regulate chromatin state, transcription, RNA stability, and translation of the gene.

Researchers at UCL have developed a therapeutic RNA molecule that corresponds with an AS-lncRNA, which can modulate the expression of a target gene. This has potential as a novel therapy for diseases where therapeutic gene suppression is desirable, for example therapeutic reduction of the tau protein in Alzheimer's Disease and other tauopathies.
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On-Belt Tomosynthesis – A Low Cost 3D Imaging System

Professor Robert Speller and his team at University College London have developed a novel On-Belt Tomosynthesis system with the potential to produce high quality 3D composite images, at low cost, whilst baggage remains in transit through an airport conveyor system. This technology is currently available for licensing and UCL Business PLC, UCL wholly owned commercialisation company, are actively seeking partners for onward development.
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Novel Method of Analysis of Stroke Data

Stroke is the leading cause of adult disability in the UK at an estimated overall annual cost of £7 billion. Clinical outcomes in stroke are not improving as fast as conditions of similar aetiology. A major cause is the difficulty in providing targeted care in a patient group with such hugely diverse requirements.

UCL has developed a system for predicting clinical outcomes so as to provide advance information on the optical clinical management of each patient.
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Magnetic Hyperthermia Device for Healthcare and Industrial Applications

Exposure of magnetic nanoparticles to an alternating magnetic field results in localised heating which can kill cells in the immediate vicinity of the heated nanoparticles. This device may be useful for antimicrobial and cancer treatment or for numerous industrial applications.
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Self-Disinfecting Computer Keyboard

Ambient lighting conditions activate a proprietary keyboard surface resulting in disinfection. These keyboards can be used in healthcare facilities to help prevent the spread of healthcare acquired infections (HCAIs).
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