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Biopharm

New lentiviral platform eliminating packaging sequences from the transcribed DNA region

Available for: Exclusive/Non-exclusive LicensingSummaryAll lentiviral vectors described to date contain packaging sequences necessary for the viral RNA genome to be assembled into viral particles. These sequences are unnecessarily reverse transcribed into DNA and permanently integrate into target cells. The researchers at UCL Institute of Child Health have developed a lentiviral platform which does not reverse

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Biopharm

Early Diagnosis of Alzheimer's Disease

Early Diagnosis of Alzheimer’s DiseaseAvailable for: Exclusive Licensing/Non-exclusive LicensingSummaryAlzheimer Disease (AD) is the most common neurodegenerative disorder affecting half of all the people above 80 years of age. The available diagnostic methods are expensive and are not available to all patients. An easily detectable biomarker that could be used for diagnosis and monitoring of AD

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Biopharm

Drug Delivery System for Crossing the Blood Brain or Blood Retinal Barrier

Available For: Exclusive licensingSummaryThe blood retinal barrier (BRB), and the blood brain barrier (BBB), represent a significant impediment to drug delivery to the eye and the brain, respectively. This lack of drug penetration has resulted in diseases, such as Age-related Macular Degeneration (AMD), Alzheimer’s Disease and Stroke being extremely difficult to address.Although therapies to eye

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Biopharm

H4R antagonists for uveitis and other inflammatory diseases

Available For: Exclusive LicensingSummaryHistamine is a pleiotropic mediator involved in a variety of physiological processes including neurotransmission, endocrine and vascular processes. It also plays a key role in inflammation and binding to one of its four receptors (H1R-H4R). Researchers at UCL Institute of Ophthalmology have shown that targeting H4R receptor in the central nervous system

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Biopharm

Antibody Tablet

Solid Dosage Form Antibody or Protein Tablet; Optimised for Ocular DeliveryAvailable For: Exclusive licensingThe Technology and its AdvantagesAntibody therapies are being used to treat highly prevalent eye diseases such as age-related macular degeneration (AMD), diabetic retinopathy, and other vascular conditions. Therapies such as the blockbuster Lucentis are currently delivered by repeat intraocular injections. Such injections

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Biopharm

Moorfields Motion Detection Test

Moorfields Motion Detection TestAvailable For: Exclusive licensingSummary Glaucoma is a leading cause of irreversible blindness and a common cause of falls in the elderly, but can be treated if detected early. Glaucoma affects around 2% of those over the age of 50 years and 5% over 80 years, with higher rates in some ethnic groups.

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Biopharm

Treatment of fibrosis with ALDH inhibitors

Treatment of fibrosis with ALDH inhibitorsAvailable for: Exclusive LicensingSummaryFibrosis is the formation of excess fibrous connective tissue in response to injury and inflammation. If it happens in response to injury it is also referred to as scarring. Fibrosis is associated with conditions such as cystic fibrosis, cirrhosis, mucous membrane pemphigoid (MMP), pulmonary fibrosis and scleroderma.

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Biopharm

Novel Therapy for Polycystic Kidney Disease (PKD)

Available for: Exclusive/Non-Exclusive LicensingSummaryPolycystic kidney disease is the most common inherited cause of kidney failure, affecting 1 in 1000 adults and children worldwide. It is characterized by the growth of multiple cysts leading to loss of normal kidney structure and functions and often results in end-stage renal disease. The researchers at UCL Institute of Child

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Biopharm

Modulating Sonic Hedgehog signalling for treatment of Autoimmune Disease and Inflammation

Available for: Exclusive/Non-exclusive licensingSummaryChronic inflammation plays role in diseases such as asthma, atopic skin conditions and cancer. On the molecular level, inflammation is driven by T-helper cells and researchers at UCL Institute of Child Health discovered that the Sonic Hedgehogpathway modulation can shift T-cell differentiation and modify the inflammatory response. This can have potential applications

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Biopharm

New genetic marker for Age-related Macular Degeneration (AMD)

Available for: Exclusive/Non-exclusive licensingSummaryAMD is the most common cause of irreversible vision impairment in the Western world and susceptibility to it is influenced by age, environmental and genetic factors. There is currently no cure for AMD and all the efforts concentrate on managing symptoms and early detection and treatment of AMD significantly reduces vision impairment.

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