Moorfields Motion Detection Test

Glaucoma is a leading cause of irreversible blindness and a common cause of falls in the elderly, but can be treated if detected early. Glaucoma affects around 2% of those over the age of 50 years and 5% over 80 years, with higher rates in some ethnic groups. Glaucoma causes gradual loss of the field of vision of which the patient is frequently unaware until it becomes severe. In the developed world, at least 50% of glaucoma sufferers are undiagnosed, reaching 90% in the developing world. Late presentation is a major risk factor for glaucoma blindness. The Moorfields MDT is a case finding device which has been developed to reduce the burden of undiagnosed glaucoma.

Early Diagnosis of Alzheimer’s Disease

Alzheimer Disease (AD) is the most common neurodegenerative disorder affecting half of all the people above 80 years of age. The available diagnostic methods are expensive and are not available to all patients. An easily detectable biomarker that could be used for diagnosis and monitoring of AD is needed. Researchers at UCL Institute of Ophthalmology demonstrated that measuring drusen deposits in the periphery of the eye can be used as diagnostic method for AD.

Dry Eye Diagnosis and Monitoring Software

Clinicians at Moorfields Eye Hospital, the leading provider of eye health services in Europe have developed the first medical device which is able to quantify dry eye in a patient. The software quantifies the number, distribution and size of fluorescein staining allowing screening, diagnosis and monitoring of the dry eye and other eye diseases.

Drug Delivery System for Crossing the Blood Brain or Blood Retinal Barrier (UDDS)

The blood retinal barrier (BRB), and the blood brain barrier (BBB), represent a significant impediment to drug delivery to the eye and the brain, respectively. This lack of drug penetration has resulted in diseases, such as Age-related Macular Degeneration (AMD), Alzheimer's Disease and Stroke being extremely difficult to address.

Although therapies to eye disease such as AMD already exist, they are delivered by intraocular injections with high risk of side effects related to the administration, the most significant being retinal detachment. The current challenge is to develop drug-delivery systems that ensure transitions across these barriers in a safe and effective manner.

Self-Disinfecting Computer Keyboard

Ambient lighting conditions activate a proprietary keyboard surface resulting in disinfection. These keyboards can be used in healthcare facilities to help prevent the spread of healthcare acquired infections (HCAIs).

Stem Cell Therapy Replacement for Retinal Ganglion Cells: Treatment for Glaucoma and Other Eye Diseases

Glaucoma is disease in the eye characterised by the progressive loss of retinal ganglion cells. Stem cell based therapeutics provide a method for restoration of neurons damaged by retinal disease. We have identified a population of neural stem cells in the adult human eye that can be isolated from donor retina. Stem cells can differentiate into retinal neurons in vitro and in vivo following transplantation into animal models of retinal degeneration.

Novel Method of Analysis of Stroke Data

Stroke is the leading cause of adult disability in the UK at an estimated overall annual cost of £7 billion. Clinical outcomes in stroke are not improving as fast as conditions of similar aetiology. A major cause is the difficulty in providing targeted care in a patient group with such hugely diverse requirements.

UCL has developed a system for predicting clinical outcomes so as to provide advance information on the optical clinical management of each patient.