Stem Cell Therapy Replacement for Retinal Ganglion Cells: Treatment for Glaucoma and Other Eye Diseases

Available For: Exclusive licensing

Summary

Glaucoma is disease in the eye characterised by the progressive loss of retinal ganglion cells. Stem cell based therapeutics provide a method for restoration of neurons damaged by retinal disease. We have identified a population of neural stem cells in the adult human eye that can be isolated from donor retina. Stem cells can differentiate into retinal neurons in vitro and in vivo following transplantation into animal models of retinal degeneration.

The Technology and its Advantages

The restoration of visual function is one of the aims in vision therapy. Present treatments for severe diseases leading to blindness such as glaucoma only slow progression and do not restore visual function. We have developed a stem cell transplantation therapy which has been shown to preserve retinal integrity and attenuate the loss of retinal ganglion cell function when transplanted. We have also developed a complimentary treatment which allows the integration of such stem cells into the retina. This therapy can be used to treat and restore the vision in a range of diseases including glaucoma, diabetic retinopathy, retinitis pigmentosa and optic nerve injury.

Market Opportunity

According to Business Insights the forecast of prevalence of glaucoma across the 5 major European countries plus the US and Japan is set to rise from 15m in 2010 to 15.7m by 2014. These figures do not include the high incidence of glaucoma in India and China. In 2008 the sales of anti-glaucoma preparations by the 10 leading companies in the market was $5,124m and showed a growth of 11% growth for the period 2007-08.

Intellectual Property Status

The Stem Cell Therapy is protected by two patents.

Further Information

Please contact Dr Rachel Hemsley, Senior Business Manager | T: +44 (0) 20 7679 9000 | E: r.hemsley@uclb.com

The technology referred to herein is experimental in nature and UCL Business PLC makes no representations and gives no warranties of any kind, either express or implied, in relation to the technology and, in particular but without limiting the foregoing, UCL Business PLC gives no express or implied warranties of merchantability, satisfactory quality or fitness for a particular purpose.