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Biopharm

Synthetic engineered potassium channel (EKC) for gene therapy (KCNA1 Kv1.1 channel)

<h1>Synthetic engineered potassium channel (EKC) for gene therapy</h1>Available For: LicensingSummaryEpilepsy affects around 60 million people globally and there remains an urgent need for novel treatment methods. Researchers at UCL Institute of Neurology have developed a novel synthetic engineered potassium channel (EKC) as a gene therapy tool to treat epilepsy and other neurological conditions. The inventors

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Biopharm

Tau-gene-specific non-coding RNA genes for the therapeutic reduction of tau levels

Available for: Exclusive/Non-Exclusive licensingSummaryDuring genome transcription, both coding and non-coding transcripts are generated with a wide range of both size and coding potential. Among these are long non-coding RNA (lncRNA) genome transcripts, some of which are antisense to protein-coding genes (AS-lncRNAs). These AS-lncRNAs have been shown to regulate chromatin state, transcription, RNA stability, and translation

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Medical Devices

Device and method for force measurement in simulated minimal invasive surgery

<h1>Device and method for force measurement in simulated minimal invasive surgery</h1>Available For: LicensingSummaryA training device for minimally invasive surgery with built-in force sensing.The Technology and its Advantages The demand for ‘minimally invasive’, ‘laparoscopic’ or ‘key-hole’ surgery techniques has increased in recent years driven by factors such as increasing healthcare costs, rising focus on patient safety

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Biopharm

LipoGlucoCEST - Novel Imaging Agents for GlucoCEST

<h1>LipoGlucoCEST – Novel Imaging Agents for GlucoCEST</h1>Available For: LicensingSummaryGlucoCEST is a magnetic resonance imaging (MRI) technique that enables visualisation of natural, non-radioactive glucose that can be used in cancer diagnosis. However, this technique has limitations due to interactions with the body glucose sensing system. To solve this problem, researchers at UCL Institute of Neurology and

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External Projects

OpSAFE

Available For: Exclusive or Non-Exclusive licenseSummaryOpSAFE is a medical device that enables touch free use of OsiriX MD image viewer for medical images.The Technology and its AdvantagesFully CE marked, the OpSAFE device comprises plug in software, foot pedal and LEAP motion controller. Staff can remain scrubbed in and there is no need for an additional

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Physical Sciences

Non-Volatile Memory - Resistive Random Access Memory RRAM

Available for: Licensing and Joint DevelopmentSummaryResearch within the Department of Electronic and Electrical Engineering (E&EE) at UCL has led to the realisation of a new memory device, based on resistive switching which has the potential to be integrated directly onto silicon. The memory device exhibits very fast switching with high resistance contrast, requiring low switching

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Physical Sciences

III-V laser diodes on germanium substrates

Available For: Licensing and joint developmentSummaryThe Photonics Research Group at UCL have recently developed and demonstrated a monolithically integrated III-V compound semiconductor photonic structure on a Silicon substrate. The monolithic III-V on Silicon device opens up new possibilities for integrated system-on-a-chip designs with high bandwidth and high data transfer rates. The Technology and Its AdvantagesThe

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Biopharm

New lentiviral platform eliminating packaging sequences from the transcribed DNA region

Available for: Exclusive/Non-exclusive LicensingSummaryAll lentiviral vectors described to date contain packaging sequences necessary for the viral RNA genome to be assembled into viral particles. These sequences are unnecessarily reverse transcribed into DNA and permanently integrate into target cells. The researchers at UCL Institute of Child Health have developed a lentiviral platform which does not reverse

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Biopharm

Treatment of fibrosis with ALDH inhibitors

Available for: Exclusive LicensingSummaryFibrosis is the formation of excess fibrous connective tissue in response to injury and inflammation. If it happens in response to injury it is also referred to as scarring. Fibrosis is associated with conditions such as cystic fibrosis, cirrhosis, mucous membrane pemphigoid (MMP), pulmonary fibrosis and scleroderma. It is also a consequence

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Biopharm

Novel Therapy for Polycystic Kidney Disease (PKD)

Available for: Exclusive/Non-Exclusive LicensingSummaryPolycystic kidney disease is the most common inherited cause of kidney failure, affecting 1 in 1000 adults and children worldwide. It is characterized by the growth of multiple cysts leading to loss of normal kidney structure and functions and often results in end-stage renal disease. The researchers at UCL Institute of Child

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