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Biopharm

Imatinib and other ABL inhibitors to treat ocular neovascularisation

Available for: Exclusive LicensingSummaryRetinal and choroidal diseases are the most common cause of vision loss in the western world. They are either caused by the leakage and neovasculatisation from retinal vessels (diabetic retinopathy, retinal vein occlusions, retinopathy of prematurity and neovascular glaucoma) or by new vessels growing into the retina and subretinal space (AMD, ocular

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Biopharm

Leukocyte labelling for detecting inflammation

Available for: Exclusive/Non-Exclusive licensingSummaryInflammation plays a role in many diseases including sight-threatening diseases of the eye such as uveitis. Recently, inflammation has also been shown to drive the processes of pathological angiogenesis in Age-related Macular Degeneration (AMD) and Diabetic Retinopathy (DR). Current methods for monitoring inflammation have limits and include direct visualisation by endoscope, PET

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Biopharm

New lentiviral platform eliminating packaging sequences from the transcribed DNA region

Available for: Exclusive/Non-exclusive LicensingSummaryAll lentiviral vectors described to date contain packaging sequences necessary for the viral RNA genome to be assembled into viral particles. These sequences are unnecessarily reverse transcribed into DNA and permanently integrate into target cells. The researchers at UCL Institute of Child Health have developed a lentiviral platform which does not reverse

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Biopharm

Treatment of fibrosis with ALDH inhibitors

Available for: Exclusive LicensingSummaryFibrosis is the formation of excess fibrous connective tissue in response to injury and inflammation. If it happens in response to injury it is also referred to as scarring. Fibrosis is associated with conditions such as cystic fibrosis, cirrhosis, mucous membrane pemphigoid (MMP), pulmonary fibrosis and scleroderma. It is also a consequence

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External Projects

OpSAFE

Available For: Exclusive or Non-Exclusive licenseSummaryOpSAFE is a medical device that enables touch free use of OsiriX MD image viewer for medical images.The Technology and its AdvantagesFully CE marked, the OpSAFE device comprises plug in software, foot pedal and LEAP motion controller. Staff can remain scrubbed in and there is no need for an additional

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Biopharm

Novel Therapy for Polycystic Kidney Disease (PKD)

Available for: Exclusive/Non-Exclusive LicensingSummaryPolycystic kidney disease is the most common inherited cause of kidney failure, affecting 1 in 1000 adults and children worldwide. It is characterized by the growth of multiple cysts leading to loss of normal kidney structure and functions and often results in end-stage renal disease. The researchers at UCL Institute of Child

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Biopharm

H4R antagonists for uveitis and other inflammatory diseases

Available For: Exclusive LicensingSummaryHistamine is a pleiotropic mediator involved in a variety of physiological processes including neurotransmission, endocrine and vascular processes. It also plays a key role in inflammation and binding to one of its four receptors (H1R-H4R). Researchers at UCL Institute of Ophthalmology have shown that targeting H4R receptor in the central nervous system

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Biopharm

Lrg-1 antagonists: Direct effect upon cancer cells

Available for: Exclusive/Non-exclusive licensingSummaryThe formation of new blood vessels by angiogenesis is a key feature of number of diseases including Age-related Macular Degeneration (AMD), Proliferative Diabetic Retinopathy (PDR), atherosclerosis, rheumatoid arthritis and cancer. Vascular Endothelial Growth Factors (VEGFs) and their receptors have been previously identified as targets for therapy of these diseases but their success

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Biopharm

Formulations for the Prevention of Neural Tube Defects

Available for: LicenseSummaryExploring ways to prevent birth defects, researchers at the UCL Institute of Child Health have discovered novel supplements that if taken in pregnancy can reduce the chance of the baby having neural tube defects such as spina bifida or anencephaly. These are important in pregnancies where folic acid and other supplements are not

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Biopharm

Drusen Diagnostic

Available for: Exclusive/Non-exclusive licensingSummaryAMD is the most common cause of irreversible vision impairment in the Western world. There is currently no cure for AMD and all the efforts concentrate on managing symptoms and early detection and treatment of AMD significantly reduces vision impairment. Most patients are diagnosed at advanced stages of the disease, while screening,

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