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Biopharm

Formulations for the Prevention of Neural Tube Defects

Exploring ways to prevent birth defects, researchers at the UCL Institute of Child Health have discovered novel supplements that if taken in pregnancy can reduce the chance of the baby having neural tube defects such as spina bifida or anencephaly. These are important in pregnancies where folic acid and other supplements are not as effective. A new patent has been filed we are supporting work to validate and test combinations in animal models.

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Biopharm

Novel Therapy for Polycystic Kidney Disease (PKD)

Polycystic kidney disease is the most common inherited cause of kidney failure, affecting 1 in 1000 adults and children worldwide. It is characterized by the growth of multiple cysts leading to loss of normal kidney structure and functions and often results in end-stage renal disease. The researchers at UCL Institute of Child Health have demonstrated that treatment with VEGF-C improved disease severity in animal models of PKD.

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Biopharm

Magnetic Targeting of Cells using MR Imaging Gradients

UCL researchers have developed a novel technique to magnetically target cells using MRI. This allows image guided targeted delivery of cells to sites of the body which cannot be reached with external permanent magnets.

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Biopharm

New lentiviral platform eliminating packaging sequences from the transcribed DNA region

All lentiviral vectors described to date contain packaging sequences necessary for the viral RNA genome to be assembled into viral particles. These sequences are unnecessarily reverse transcribed into DNA and permanently integrate into target cells. The researchers at UCL Institute of Child Health have developed a lentiviral platform which does not reverse transcribe the packaging sequences into the target cells.

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Medical Devices

Device and method for force measurement in simulated minimal invasive surgery

A training device for minimally invasive surgery with built-in force sensing.

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Engineering

Delivery Device for Percutaneous Heart Valve

Delivery and recapture system and method for transcatheter prosthetic devices.

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Engineering

Superior X-Ray Imaging for Early Detection of Breast Cancer

Professor Robert Speller and his team at University College London have developed a novel phase contrast x-ray technology with the potential for improved image quality and enhanced diagnostic potential when applied to mammography. This technology will provide earlier more accurate detection of breast cancers when compared to current clinical practices.

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Engineering

Bioactive Coating

A novel method of creating an inter-locked (high bond strength) bioactive coating on metallic substrates for orthopaedic applications.

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Engineering

Novel Percutaneous Heart Valve

A novel design of artificial aortic valve for transcatheter implantation.

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Biopharm

Voltage-Gated Sodium Channel Knockout Mice: Tools for Developing Therapeutics for the Treatment of Pain

Scientists at University College London have developed Voltage-Gated Sodium Channel subtype specific conditional knockout mice which provide invaluable tools for the development of therapeutics for the treatment of pain.

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