Novel UCL Nanocomposite Polymer and its Unique Role in the Field of Biomedical Devices
Our novel nanocomposite polymer (NC) can uniquely achieve complete tissue and blood compatibility, unlike conventional medical polymers such as PTFE and Dacron. This offers exciting possibilities for medical device manufacturers.
| Date added | 18 Jan 2008 |
|---|---|
| Reference number | 94-092 |
| Status | PCT Application has been filed, priority date 20th January 2004, Application Number PCT/GB05/000189 |
| Availability | Exclusive and non exclusive licensing opportunities |
| References | [Blank] |
The technology and its advantages
The NC is based on Silsesquioxane, and exhibits unique surface properties. It preferentially adsorbs and deactivates fibrinogen, thus preventing activation of the coagulation cascades, inflammation and growth of tissue capsule.
A new synthesis route allows preparation of the NC so that it has controlled properties. This is achieved by introducing Silsequioxanes as pendant groups into the backbone of the polymer. Uniquely there is no degradation by hydrolysis or oxidation. However, variants of the NC can also be produced so that controlled degradation will occur, making these variants suitable candidates for tissue engineering scaffolds. In addition the NC can be manipulated, for example by attachment of drugs, gene vectors or other biomolecules relevant to the applications.
The NC is not toxic to cells and supports the adhesion and growth of cells in vitro. Furthermore, the NC inhibits protein absorption by prolonging the coagulation time. This prevents thrombogenicity and non-compatibility with blood, which together are the second principal reason behind failure of material surfaces of medical devices.
A three-year in vivo implantation study in a large animal model has confirmed in vitro findings that the NC is biocompatible, non-toxic, and shows no evidence of degradation, inflammation or capsule formation. As the NC is not drug based, CE and FDA approval are more easily achievable and so offer the device manufacturer unique opportunities.
Market opportunity
The physical properties of the NC are such that it can be tailored to many specific medical device applications, for example:
• Coronary artery bypass grafts – the NC can be made more elastic to closely mimic the elasticity of arteries
• Coating of coronary stents – the NC supports the adhesion and growth of cells, including endothelial cells
• Tissue scaffolds – the NC can be tailor-made to be degradable under controlled conditions
• Condoms and surgical gloves – the NC is thin and strong and retains its original shape
The NC will allow manufacturers to market a broad spectrum of safer, more efficient medical devices and other products.
Further information
Please contact: Karen Cheetham, UCL Business PLC
T +44 (0)20 7679 9000 E k.cheetham@uclb.com
