Available technologies2018-09-25T17:57:47+00:00

Available technologies

Stem Cell Therapy Replacement for Retinal Ganglion Cells: Treatment for Glaucoma and Other Eye Diseases

Glaucoma is disease in the eye characterised by the progressive loss of retinal ganglion cells. Stem cell based therapeutics provide a method for restoration of neurons damaged by retinal disease. We have identified a population of neural stem cells in the adult human eye that can be isolated from donor retina. Stem cells can differentiate into retinal neurons in vitro and in vivo following transplantation into animal models of retinal degeneration.
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Diagnosing Apoptosing Retinal Cells: Diagnostic for Glaucoma & Alzheimers Disease

DARC: the Diagnosis of Apoptosing Retinal Cells is a new early stage diagnostic method for glaucoma, Alzheimer's and other neurodegenerative diseases. DARC can also be used as an end point marker for the evaluation of neuroprotective drugs.
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Drug Delivery System for Crossing the Blood Brain or Blood Retinal Barrier (UDDS)

The blood retinal barrier (BRB), and the blood brain barrier (BBB), represent a significant impediment to drug delivery to the eye and the brain, respectively. This lack of drug penetration has resulted in diseases, such as Age-related Macular Degeneration (AMD), Alzheimer's Disease and Stroke being extremely difficult to address.

Although therapies to eye disease such as AMD already exist, they are delivered by intraocular injections with high risk of side effects related to the administration, the most significant being retinal detachment. The current challenge is to develop drug-delivery systems that ensure transitions across these barriers in a safe and effective manner.
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Antibody Tablet for Occular Therapeutics Delivery

A novel solid formulation for the delivery of antibodies and protein therapeutics into the eye. This has several advantages over current methodologies which involve painful intraocular injections.
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Dry Eye Diagnosis and Monitoring Software

Clinicians at Moorfields Eye Hospital, the leading provider of eye health services in Europe have developed the first medical device which is able to quantify dry eye in a patient. The software quantifies the number, distribution and size of fluorescein staining allowing screening, diagnosis and monitoring of the dry eye and other eye diseases.
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Magnetic Microbubbles

Magnetic microbubbles can be injected into the blood stream and may be directed to a specific body location by the application of an external magnetic field. They enhance ultrasound images, and can be used to deliver, and promote uptake of, cargo molecules such as drugs, antibodies or DNA. They thus have many potential applications in clinical settings, as well as in both basic and medical research.
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New Micro-Cantilever Configuration

A team at London Centre for Nanotechnology are developing a device that is already being used to detect the presence viruses, bacteria and proteins from a single sample. It is based on a cantilever sensing method and is configured to give binding energy information as well as a quantative assay. The new system has already displaced use of the commercially available system in the Lab as the virologists find the new configuration much easier to use. The project is currently supported by the EPSRC for research on HIV management.
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Ultra-Fast Fluidic Analysis

A research group at UCL have developed a new microfluidic-based method which can be used in combination with either chemical or optical heating-based denaturation to measure protein stability curves and calculate affinity constants from nanolitre sample volumes.

Measurement times are significantly reduced from standard methods and envisaged applications range from high-throughput drug discovery to healthcare diagnostics and pathogen detection.
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Non-Volatile Memory – Resistive Random Access Memory RRAM

Research within the Department of Electronic and Electrical Engineering (E&EE) at UCL has led to the realisation of a new memory device, based on resistive switching which has the potential to be integrated directly onto silicon. The memory device exhibits very fast switching with high resistance contrast, requiring low switching energies and persist for extended periods of time.
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Passive Wireless Detection System

A team of researchers at UCL's Department of Electronic and Electrical Engineering, have developed a method for detection and tracking using existing wireless signals (WiFi) present in the everyday environment.
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