Drug Delivery System for Crossing the Blood Brain or Blood Retinal Barrier (UDDS)

2020-06-10T15:58:02+01:00

The blood retinal barrier (BRB), and the blood brain barrier (BBB), represent a significant impediment to drug delivery to the eye and the brain, respectively. This lack of drug penetration has resulted in diseases, such as Age-related Macular Degeneration (AMD), Alzheimer's Disease and Stroke being extremely difficult to address.

Although therapies to eye disease such as AMD already exist, they are delivered by intraocular injections with high risk of side effects related to the administration, the most significant being retinal detachment. The current challenge is to develop drug-delivery systems that ensure transitions across these barriers in a safe and effective manner.

Drug Delivery System for Crossing the Blood Brain or Blood Retinal Barrier (UDDS)2020-06-10T15:58:02+01:00

Early Diagnosis of Alzheimer’s Disease

2020-06-10T14:52:30+01:00

Alzheimer Disease (AD) is the most common neurodegenerative disorder affecting half of all the people above 80 years of age. The available diagnostic methods are expensive and are not available to all patients. An easily detectable biomarker that could be used for diagnosis and monitoring of AD is needed. Researchers at UCL Institute of Ophthalmology demonstrated that measuring drusen deposits in the periphery of the eye can be used as diagnostic method for AD.

Early Diagnosis of Alzheimer’s Disease2020-06-10T14:52:30+01:00

Self-Disinfecting Computer Keyboard

2020-06-10T14:52:30+01:00

Ambient lighting conditions activate a proprietary keyboard surface resulting in disinfection. These keyboards can be used in healthcare facilities to help prevent the spread of healthcare acquired infections (HCAIs).

Self-Disinfecting Computer Keyboard2020-06-10T14:52:30+01:00

Dry Eye Diagnosis and Monitoring Software

2020-06-10T14:52:30+01:00

Clinicians at Moorfields Eye Hospital, the leading provider of eye health services in Europe have developed software which is able to quantify dry eye in a patient. The software quantifies the number, distribution and size of fluorescein staining allowing screening, diagnosis and monitoring of the dry eye and other eye diseases.

Dry Eye Diagnosis and Monitoring Software2020-06-10T14:52:30+01:00

Formulations for the Prevention of Neural Tube Defects

2020-06-10T14:52:30+01:00

Exploring ways to prevent birth defects, researchers at the UCL Institute of Child Health have discovered novel supplements that if taken in pregnancy can reduce the chance of the baby having neural tube defects such as spina bifida or anencephaly. These are important in pregnancies where folic acid and other supplements are not as effective. A new patent has been filed we are supporting work to validate and test combinations in animal models.

Formulations for the Prevention of Neural Tube Defects2020-06-10T14:52:30+01:00

New lentiviral platform eliminating packaging sequences from the transcribed DNA region

2020-06-10T14:52:30+01:00

All lentiviral vectors described to date contain packaging sequences necessary for the viral RNA genome to be assembled into viral particles. These sequences are unnecessarily reverse transcribed into DNA and permanently integrate into target cells. The researchers at UCL Institute of Child Health have developed a lentiviral platform which does not reverse transcribe the packaging sequences into the target cells.

New lentiviral platform eliminating packaging sequences from the transcribed DNA region2020-06-10T14:52:30+01:00

Synthetic engineered potassium channel (EKC) for gene therapy

2020-03-09T00:03:07+00:00

Epilepsy affects around 60 million people globally and there remains an urgent need for novel treatment methods. Researchers at UCL Institute of Neurology have developed a novel synthetic engineered potassium channel (EKC) as a gene therapy tool to treat epilepsy and other neurological conditions. The inventors have preclinical results demonstrating their engineered potassium channel reduces seizures in a rodent model of epilepsy.

Synthetic engineered potassium channel (EKC) for gene therapy2020-03-09T00:03:07+00:00

LipoGlucoCEST – Novel Imaging Agents for GlucoCEST

2020-03-09T00:03:07+00:00

GlucoCEST is a magnetic resonance imaging (MRI) technique that enables visualisation of natural, non-radioactive glucose that can be used in cancer diagnosis. However, this technique has limitations due to interactions with the body glucose sensing system.

To solve this problem, researchers at UCL Institute of Neurology and Department of Chemistry have developed a novel set of imaging agents based on liposome-encapsulated sugar compounds that addresses these issues.

LipoGlucoCEST – Novel Imaging Agents for GlucoCEST2020-03-09T00:03:07+00:00

Collagen for tendon repair

2020-03-09T00:03:07+00:00

Collagen is the most widely distributed class of proteins in the human body and the use of collagen-based biomaterials in the field of tissue engineering is extensive. However collagen hydrogels typically have low mechanical strength, and accordingly may not be suitable for use in tendon and other tissue repair grafts without further processing. Whilst there are methods available to increase the strength of collagen, they are not suitable for fabrication of certain tissues as the shape of tissue needs to be “crafted” which leads to structural weakness, layer separation and heterogeneous cell distribution.

Collagen for tendon repair2020-03-09T00:03:07+00:00