The LIGPLOT software program automatically generates schematic 2-D representations of protein-ligand complexes from standard Protein Data Bank file input. The output is a colour or black-and-white PostScript file giving simple and informative representation of the intermolecular interactions, including hydrogen bonds and hydophyobic interactions. A java-based editor called LigEd allows the final plot to be interactively modified and fine-tuned if necessary.
A team of researchers at UCL's Department of Electronic and Electrical Engineering, have developed a method for detection and tracking using existing wireless signals (WiFi) present in the everyday environment.
A research group at UCL have developed a new microfluidic-based method which can be used in combination with either chemical or optical heating-based denaturation to measure protein stability curves and calculate affinity constants from nanolitre sample volumes.
Measurement times are significantly reduced from standard methods and envisaged applications range from high-throughput drug discovery to healthcare diagnostics and pathogen detection.
Professor Robert Speller and his team at University College London have developed a novel On-Belt Tomosynthesis system with the potential to produce high quality 3D composite images, at low cost, whilst baggage remains in transit through an airport conveyor system. This technology is currently available for licensing and UCL Business PLC, UCL wholly owned commercialisation company, are actively seeking partners for onward development.
The Photonics Research Group at UCL have recently developed and demonstrated a monolithically integrated III-V compound semiconductor photonic structure on a Silicon substrate. The monolithic III-V on Silicon device opens up new possibilities for integrated system-on-a-chip designs with high bandwidth and high data transfer rates.
Research within the Department of Electronic and Electrical Engineering (E&EE) at UCL has led to the realisation of a new memory device, based on resistive switching which has the potential to be integrated directly onto silicon. The memory device exhibits very fast switching with high resistance contrast, requiring low switching energies and persist for extended periods of time.
Magnetic microbubbles can be injected into the blood stream and may be directed to a specific body location by the application of an external magnetic field. They enhance ultrasound images, and can be used to deliver, and promote uptake of, cargo molecules such as drugs, antibodies or DNA. They thus have many potential applications in clinical settings, as well as in both basic and medical research.
A team at London Centre for Nanotechnology are developing a device that is already being used to detect the presence viruses, bacteria and proteins from a single sample. It is based on a cantilever sensing method and is configured to give binding energy information as well as a quantative assay. The new system has already displaced use of the commercially available system in the Lab as the virologists find the new configuration much easier to use. The project is currently supported by the EPSRC for research on HIV management.
Exposure of magnetic nanoparticles to an alternating magnetic field results in localised heating which can kill cells in the immediate vicinity of the heated nanoparticles. This device may be useful for antimicrobial and cancer treatment or for numerous industrial applications.
